Role of protein modifications mediated by transglutaminase 2 in human viral diseases.
نویسندگان
چکیده
Transglutaminase 2 (TG2) belongs to a family of calcium-dependent enzymes that catalyze transamidation reaction, producing polymerized, polyaminated or deamidated proteins. Recently, a growing number of viral proteins as well as cellular proteins with which they interact have been found to be modified by TG2, suggesting a novel function for TG2 in viral pathogenesis. This review summarizes the results of relevant research, examines the mechanisms underlying TG2 function in host-virus interactions and proposes a model for viral pathogenesis involving TG2.
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ورودعنوان ژورنال:
- Frontiers in bioscience : a journal and virtual library
دوره 11 شماره
صفحات -
تاریخ انتشار 2006